Ipamorelin Selective GH Secretagogue Research
Ipamorelin research hub — the most selective growth hormone secretagogue, ghrelin receptor agonist mechanisms, cortisol-sparing profile, bone density, GI motility, and combination research.
Featured Research
In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Ipamorelin Acetate
Also known as: Ipamorelin, NNC 26-0161
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). Unlike earlier GHS compounds such as GHRP-6 and GHRP-2, ipamorelin is notable for its high selectivity — it stimulates growth hormone release without significantly affecting cortisol, prolactin, or ACTH levels at GH-stimulating doses. Th...
Quick Facts
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
MW: 711.85 g/mol
CAS: 170851-70-4
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C and used within 28 days. Relativ...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
Ipamorelin: The Selective Growth Hormone Secretagogue
Research review of Ipamorelin — the highly selective GHS-R agonist studied for growth hormone release without significan...
Read Article Peptide Deep DiveCJC-1295 + Ipamorelin: The Combination Research Protocol
Why CJC-1295 and Ipamorelin are combined in research — complementary receptor targets, synergistic GH release, and study...
Read Article Category RoundupGrowth Hormone Secretagogues: A Complete Research Guide
Everything researchers need to know about GH secretagogues — Ipamorelin, CJC-1295, GHRP-6, Tesamorelin, and how they dif...
Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Lean Mass & Body Composition
Combined with CJC-1295, this is the most cited stack for increasing growth hormone — promoting lean muscle growth and fat metabolism without increasing hunger or cortisol.
Weight Loss & Fat Metabolism
Ipamorelin/CJC-1295 combination increases natural growth hormone production, helping reduce fat while maintaining lean mass — all with a clean hormonal profile.
Sleep Optimization
Stimulates growth hormone release which peaks during deep sleep, leading to more restorative rest, better tissue repair, and increased energy without appetite side effects.
Recovery & Healing
Boosts natural growth hormone levels which speeds up tissue repair and reduces recovery time. Ipamorelin's cortisol-sparing profile makes it ideal for recovery research.
Bone & Musculoskeletal
Studied in ovariectomized rat models for bone density improvements and in GI motility research for post-operative ileus recovery.
Frequently Asked Questions
Common questions about ipamorelin research research, purity standards, and sourcing.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that selectively binds the ghrelin receptor (GHS-R1a). It stimulates dose-dependent GH release without significantly affecting cortisol, prolactin, ACTH, or appetite — the cleanest hormonal profile of any GH secretagogue.
Why is Ipamorelin considered the most selective GH secretagogue?
Unlike GHRP-6 and Hexarelin which increase cortisol, prolactin, and appetite alongside GH, Ipamorelin produces GH release with minimal off-target hormonal effects. This selectivity makes it the preferred tool for studying isolated GH-axis effects.
What research applications does Ipamorelin have?
Ipamorelin is studied for GH-axis research, bone density (ovariectomized rat models), GI motility (post-operative ileus), body composition, and as a pharmacological tool for isolating GH-dependent effects from cortisol/prolactin confounders.
Ready to Start Your Research?
Browse our complete research library or visit Research Vials to source peptides.
Explore the System Peptides Research Network